The Pueblo Revolt of 1680

(Wikipedia) The Pueblo Revolt of 1680 — also known as Popé's Rebellion — was an uprising of most of the indigenous Pueblo people against the Spanish colonizers in the province of Santa Fe de Nuevo México, present day New Mexico. The Pueblo Revolt killed 400 Spanish and drove the remaining 2,000 settlers out of the province.
... For more than 100 years beginning in 1540, the Pueblo Indians of present-day New Mexico were subjected to successive waves of soldiers, missionaries, and settlers. These encounters, referred to as the Entradas, were characterized by violent confrontations between Spanish colonists and Pueblo peoples. The Tiguex War, fought in the winter of 1540-41 by the expedition of Francisco Vásquez de Coronado against the twelve or thirteen pueblos of Tiwa Indians, was particularly destructive to Pueblo and Spanish relations. Continued